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肝脏是胎儿时期的主要造血器官,鼠胚胎12～15d和人胚胎6周至4月是肝脏造血活跃期。在个体发育阶段上,胎肝造血干细胞(HSCs)较骨髓造血干细胞原始;从生理需求角度讲。骨髓HSCs的功能是维持终生造血稳定,其分裂采取群体不对称方式,因此骨髓HSCs数目在人体内保持恒定。而胎肝造血是处于由胚胎造血系统分化形成转向为胎儿日益扩张的循环容量和氧需提供足够红细胞的过渡时期,因此,胎肝HSCs有一个对称分裂以增加自身数目的性能和过程,以便为终生造血稳定提供足够的干细胞贮
The liver is the major hematopoietic organ in the fetal period. The mouse embryos 12 to 15 days and human embryos from 6 weeks to April are the active stages of liver hematopoiesis. In the individual development stage, fetal liver hematopoietic stem cells (HSCs) than the original bone marrow hematopoietic stem cells; from the physiological point of view. The function of bone marrow HSCs is to maintain lifelong hematopoietic stability, the split to take a population asymmetry, so the number of bone marrow HSCs remain constant in the human body. Fetal liver hematopoiesis is in the process of embryonic hematopoietic system differentiation to form the expanding cycle capacity for the fetus and the transition period of oxygen to provide enough red blood cells. Therefore, fetal liver HSCs have a symmetrical division to increase their own number of properties and processes in order to Lifetime hematopoiesis provides enough stem cell storage