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目的探讨Survivin、Ki-67在口腔颌面部原发性非霍奇金淋巴瘤(NHL)中的表达及其与组织学表型的关系。方法采用免疫组织化学En Vision通用型二步法检测39例口腔颌面部原发性NHL组织中Survivin、Ki-67的表达情况,分析两者的相关性及其与组织学表型的关系。同时选取20例经病理组织学检查确诊的淋巴结炎组织作对照。结果 NHL组织中Survivin和Ki-67的阳性表达率分别为66.7%(26/39)和71.8%(28/39),高于淋巴结炎组织的20.0%(4/20)和10.0%(2/20),差异均有统计学意义(P<0.05);NHL中结内型和结外型的Survivin和Ki-67阳性表达率亦均高于淋巴结炎组织(P<0.05),而NHL结内型与结外型阳性表达率的差异无统计学意义(P>0.05)。在NHL中,高度恶性者Survivin和Ki-67阳性表达率均高于低度恶性者(P<0.05);Survivin(r=0.471,P=0.018)和Ki-67(r=0.691,P=0.000)表达均与NHL组织学表型呈正相关。结论 Survivin、Ki-67的表达在口腔颌面部NHL发生、发展过程中起重要作用,可作为判断预后的指标。
Objective To investigate the expression of Survivin and Ki-67 in oral and maxillofacial non-Hodgkin’s lymphoma (NHL) and its relationship with histological phenotypes. Methods The expression of Survivin and Ki-67 in 39 cases of oral and maxillofacial primary NHL tissues was detected by immunohistochemistry En Vision universal two-step method. The correlation between them and their relationship with histological phenotypes were analyzed. Twenty cases of lymphadenitis diagnosed by histopathology were selected as controls. Results The positive rates of Survivin and Ki-67 in NHL tissues were 66.7% (26/39) and 71.8% (28/39), respectively, which were higher than those in 20.0% (4/20) and 10.0% (2 / 20). The positive rates of Survivin and Ki-67 in NHL were also higher than those in lymphadenitis (P <0.05), while those in NHL There was no significant difference in the positive expression rate between type and type (P> 0.05). The positive rates of Survivin and Ki-67 in NHL were significantly higher than those in patients with low grade (P <0.05). Survivin (r = 0.471, P = 0.018) and Ki-67 ) Expression were positively correlated with the histological phenotype of NHL. Conclusions The expression of Survivin and Ki-67 plays an important role in the occurrence and development of oral and maxillofacial NHL, which may be used as an indicator of prognosis.