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目的研究支气管肺泡灌洗液(bronchoalveolarlavagefluid,BALF)中转化生长因子β1(TGF-β1)、血小板衍生生长因子(PDGF)含量变化及细胞改变,探讨其临床应用价值。方法用ELISA方法检测BALF中TGF-β1,PDGF含量。结果特发性肺纤维化(IPF)患者支气管肺泡灌洗液中TGF-β1,PDGF含量与对照组比较明显升高(P<0.01,P<0.05)。结论TGF-β1,PDGF参与IPF的形成,检测BALF中TGF-β1,PDGF含量可作为IPF的辅助诊断指标及判断疾病活动的标志,对TGF-β1,PDGF的生物活性进行阻断,将是治疗IPF一条有前途的方法。
Objective To study the changes of the content of TGF-β1 and PDGF in bronchoalveolar fluid (BALF) and its clinical significance. Methods The contents of TGF-β1 and PDGF in BALF were detected by ELISA. Results The levels of TGF-β1 and PDGF in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis (IPF) were significantly higher than those in control group (P <0.01, P <0.05). Conclusion TGF-β1 and PDGF are involved in the formation of IPF. Detection of TGF-β1 and PDGF in BALF may be used as an auxiliary diagnostic indicator of IPF and a marker of disease activity. Blocking the biological activity of TGF-β1 and PDGF will be the treatment IPF a promising way.