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目的 :探讨膀胱癌组织蛋白酶 D(Cath- D)的表达与临床及病理的关系。方法 :应用免疫组织化学 SP法检测 85例膀胱癌中 Cath- D。结果 :总阳性表达率为 76 .4% ,Cath- D表达率与膀胱癌病理分级呈正相关 (P <0 .0 1) ,与临床分期无关。Cath- D主要表达于膀胱癌细胞浆中 ,正常膀胱变移上皮无表达。结论 :Cath- D参与了膀胱癌细胞的分化 ,对病理学分级有意义。
Objective: To investigate the relationship between the expression of cathepsin D (Cath-D) and clinicopathological features in bladder cancer. Methods: Immunohistochemical SP method was used to detect Cath-D in 85 cases of bladder cancer. Results: The positive expression rate of Cath-D was 76.4%. There was a positive correlation between the expression of Cath-D and the pathological grade of bladder cancer (P <0.01), but not with the clinical stage. Cath-D is mainly expressed in the cytoplasm of bladder cancer, normal bladder metastasis epithelial no expression. Conclusion: Cath-D is involved in the differentiation of bladder cancer cells and is of significance for the pathological grading.