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目的:研究组合型人工肾治疗尿毒症的临床疗效。方法:选取66例维持性血液透析患者,随机分为试验组和对照组各33例,试验组患者接受组合型人工肾治疗,对照组患者接受单独血液透析治疗。观察两组患者治疗前后血液中肌酐(SCr)、血尿素氮(BUN)、血常规、中分子物质(MMS)清除率以及临床症状的变化情况等。结果:治疗后,所有患者均未发生不良反应,两组患者的SCr、BUN,血常规(包括血小板计数、血红蛋白含量、血白细胞计数)均比治疗前有明显改善(P<0.05),但两组间差异无统计学意义(P>0.05);试验组患者临床症状改善和MMS清除率明显优于对照组,两组差异有统计学意义(P<0.05)。结论:组合型人工肾能有效治疗尿毒症,且效果显著,同时可以显著改善患者的临床症状,且无不良反应和副作用,弥补了单独血液透析的不足,可以在临床上广泛采用。
Objective: To study the clinical efficacy of combined artificial kidney in the treatment of uremia. Methods: Sixty-six cases of maintenance hemodialysis patients were randomly divided into experimental group and control group, with 33 cases in each group. The patients in experimental group received combined artificial kidney treatment and the control group received hemodialysis alone. The changes of blood creatinine (SCr), blood urea nitrogen (BUN), blood routine, and molecular mass (MMS) clearance and the clinical symptoms of the two groups were observed before and after treatment. Results: After treatment, no adverse reactions occurred in all patients. The SCr, BUN, blood routine (including platelet count, hemoglobin and white blood cell count) in both groups were significantly improved (P <0.05) There was no significant difference between the two groups (P> 0.05). The clinical symptoms and MMS clearance in the experimental group were significantly better than those in the control group (P <0.05). Conclusion: Combined artificial kidney can effectively treat uremia and has significant effect. At the same time, it can significantly improve the clinical symptoms of patients with no adverse reactions and side effects, which can make up for the lack of hemodialysis alone and can be widely used clinically.