The Reconstructing of Low Signal-noise Ratio Single Ion Channel Signal from Patch-clamp Recordings S

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The single ion channel signal is an ionic current that can be recorded by the patch clamp technique. Hidden Markov model(HMM)algorithm has been used to convert the low signal-noise ra-tio (SNR) noisy recording into an idealized quantal one in the case of white background noise. The traditional HMM algorithm is extended and adapted to the colored background noise.A new algorithm called EHMM (Extended HMM) algorithm is proposed,and mainly validated by simulati-on.Results show that its effective.
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