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195 7年 Margoshes和 Vallee在马的肾皮质中首先发现了金属硫蛋白(MT)。随后的研究证实 MT是一种广泛存在于细菌、真菌、植物和真核生物中的高度保守的细胞内蛋白质 ,具广泛的生物学特性 ,如参与金属离子 Cu2 + 、Zn2 +的稳态的维持 ,抗氧自由基损伤和参与调节谷氨酸能和 γ-氨
For seven years, Margoshes and Vallee first discovered metallothionein (MT) in the kidney cortex of horses. Subsequent studies confirm that MT is a highly conserved intracellular protein widely found in bacteria, fungi, plants and eukaryotes with a wide range of biological properties such as involvement in the homeostasis of Cu2 + and Zn2 + , Antioxidant free radical damage and involvement in the regulation of glutamate energy and gamma-ammonia