INTRODUCTIONrnPCa is now the commonest cancer in men in the developed world,and its incidence continues to rise worldwide as a result of prostate-specific antigen testing and ageing populations.1,2 Prostate tumourigenesis involves multistep accumulation of mutations in cancer related genes,promoting the transformation of benign epithelium to locally invasive lesions,which ultimately progress into metastases.However,information on the temporal relationship of individual genes driving prostate carcinogenesis remains scanty.PCa is also highly heterogeneous in terms of tumour morphology and behaviour,thus making it difficult to robustly develop a scheme to capture the different molecular stages of PCa development.We believe that distinct aberrant signalling events interact to drive PCa in a complex synergistic manner,and better understanding of such crosstalks will shed new insight into the underlying mechanisms driving PCa.