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酮康唑是抗糠秕马拉色菌（卵圆形糠秕孢子菌）非常有效的药物。研究证明糠秕马拉色菌在头皮单纯糠疹和脂溢性皮炎的发病机制中起重要作用，也是花斑癣的致病菌。本文研究目的是评价２％酮康唑洗剂和安慰剂洗剂治疗头皮单纯糠疹，头皮脂溢性皮炎和花斑癣的疗效和安全性。共治疗２１６例病人，结果表明：２％酮康唑洗剂疗效明显优于安慰剂洗剂。２％酮康唑剂组治疗头皮单纯糠疹５０例，对头皮鳞屑的有效率为６６．０％（安慰剂为４３．９％，Ｐ＜０．０５）；对头皮瘙痒的有效率为７１．７％（安慰剂为３０．０％，Ｐ＜０．０１）；总的疗效评价，其有效率为７０．０％（安慰剂为３９．０％，Ｐ＜０．０１）。治疗头皮脂溢性皮炎４２例，对头皮鳞屑的有效率为６３．２％（安慰剂为３４．４％，Ｐ＜０．０５）；对头皮潮红的有效率为３３．３％（安慰剂为２２．７％，Ｐ＞０．０５）；对头发油腻的有效率为６８．６％（安慰剂为２６．５％，Ｐ＜０．０１）；对头皮瘙痒的有效率为５０．０％（安慰剂为２３．５％，Ｐ＜０．０５）；总的疗效评价，其有效率为５７．１％（安慰剂为２４．３％，Ｐ＜０．０１）。治疗花斑癣２３例，临床和真菌学痊愈率为８２．６％（安慰剂为１７．４％，Ｐ＜０．０００１）。?
Ketoconazole is a very effective drug against Malassezia furfur (Pityrosporodes ovale). Studies have shown that Malassezia furfur in the scalp psoriasis and seborrheic dermatitis pathogenesis play an important role, but also the pathogen Pityles. The purpose of this study was to evaluate the efficacy and safety of 2% ketoconazole lotion and placebo lotion for the treatment of psoriasis, scalp dermatitis and tinea versicolor. A total of 216 patients were treated, the results showed that: 2% ketoconazole lotion was significantly better than the placebo lotion. In the 2% ketoconazole group, 50 cases of pityriasis of the scalp were treated, the effective rate was 66.0% for scalp scales (43.9%, P <0.05); the effective rate of scalp pruritus was 71 .7% (placebo 30.0%, P <0.01). The overall response rate was 70.0% (placebo 39.0%, P <0.01). Treatment of 42 cases of scalp seborrheic dermatitis, scalp scales on the effective rate was 63.2% (34.4% for placebo, P <0.05); on the scalp flushing efficiency was 33.3% (placebo (22.7%, P> 0.05). The effective rate of hair greasy was 68.6% (placebo was 26.5%, P <0.01). The effective rate of pruritus on the scalp was 50.0 % (Placebo = 23.5%, P <0.05). The overall response rate was 57.1% (placebo = 24.3%, P <0.01). 23 cases of pityriasis versicolor, clinical and mycological cure rate was 82.6% (placebo was 17.4%, P <0.0001). ?