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目的:制备吡喹酮脂质体凝胶(PQ-LG),并观察其治疗酒渣鼻的疗效。方法:分别制备PQ-LG及吡喹酮(PQ)凝胶;选取临床诊断为酒渣鼻Ⅰ期和Ⅱ期患者,分别用PQ-LG或PQ凝胶进行2个疗程的治疗,对两组患者的皮损程度、自觉症状、疗效评价等指标进行考察。结果:PQ-LG组的痊愈率为25.0%,有效率为65.0%,较PQ凝胶组有明显提高(P<0.05);两组患者第16周末蠕形螨计数比较,差异显著(P<0.001)。结论:PQ-LG治疗酒渣鼻的疗效明显优于PQ普通凝胶,值得进一步研发。
Objective: To prepare praziquantel liposome gel (PQ-LG) and observe its curative effect on rosacea. Methods: PQ-LG and praziquantel (PQ) gels were prepared separately. Patients with stage Ⅰ and Ⅱ clinical diagnosis of rosacea were selected and treated with PQ-LG or PQ gel for 2 courses respectively. Patients with lesions, symptoms, evaluation of efficacy and other indicators were investigated. Results: The cure rate of PQ-LG group was 25.0% and the effective rate was 65.0%, which was significantly higher than that of PQ gel group (P <0.05). There was significant difference in demodex counts at the 16th weekend in both groups (P < 0.001). Conclusion: The efficacy of PQ-LG in the treatment of rosacea is obviously superior to that of PQ gels, which deserves further research and development.