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目的:评价诺迪康胶囊治疗冠状动脉粥样硬化性心脏病(冠心病)的临床疗效及其对血小板聚集率的影响。方法:46例冠心病患者随机分2组,分别服用诺迪康胶囊和复方丹参片4周;治疗前后进行心电图和血小板聚集率(PAR)检查。结果:30例患者服诺迪康胶囊前后PAR分别为0.73±0.15和0.63±0.12(P<0.01),与对照组治疗后(0.69±0.15)比较有显著性差异(P<0.05),心绞痛临床总有效率为90.0%,明显高于对照组62.5%(P<0.05),心电图改善总有效率(61.5%)高于对照组(53.9%),但无显著差异。结论:诺迪康胶囊可明显降低PAR,改善胸痛症状及心电图STT改变。
Objective: To evaluate the clinical efficacy of Nordicum capsule in treating coronary atherosclerotic heart disease (CHD) and its effect on platelet aggregation rate. Methods: Forty-six patients with coronary heart disease were randomly divided into two groups, taking Nuodikang capsules and Fufang Danshen tablets for 4 weeks respectively. The electrocardiogram and platelet aggregation rate (PAR) were measured before and after treatment. Results: The PAR of 30 patients before and after treatment with Nuodendron capsules were 0.73 ± 0.15 and 0.63 ± 0.12 (P <0.01), respectively, which were significantly lower than those of the control group (0.69 ± 0.15 (P <0.05). The total clinical effective rate of angina pectoris was 90.0%, which was significantly higher than that of the control group (62.5%, P <0.05). The electrocardiogram improved the total effective rate (61. 5%) than the control group (53.9%), but no significant difference. Conclusion: Nuodikang capsules can significantly reduce PAR, improve the symptoms of chest pain and electrocardiogram STT changes.