乳腺癌发病率位居女性恶性肿瘤第1位,在女性肿瘤相关性疾病的死亡中占有主要地位。近年来,乳腺癌发生率及病死率有逐年上升并且有发病年龄年轻化的趋势,给乳腺癌的防治提出了挑战。乳腺癌干细胞的发现给乳腺癌的治疗研究指出了新的方向,进一步研究乳腺癌干细胞生物学行为,将能够更好地解释药物治疗的耐药、侵袭及远处转移等问题,可为临床治疗乳腺癌提供有益的指导。一、乳腺癌干细胞的发现与分离1.乳腺癌干细胞的发现:随着对肿瘤研究的深入,研究人员发现肿瘤细胞同正常组织源于组织干细胞一样,肿瘤组 The incidence of breast cancer in women ranked first in malignant tumors, cancer-related diseases in women occupy a dominant position in the death. In recent years, the incidence of breast cancer and mortality have increased year by year and the trend of younger age of onset, the prevention and treatment of breast cancer posed a challenge. The discovery of breast cancer stem cells has pointed out a new direction for the treatment of breast cancer. To further study the biological behavior of breast cancer stem cells will be able to better explain the drug resistance, invasion and distant metastasis, and other issues for clinical treatment Breast cancer provides useful guidance. First, the discovery and isolation of breast cancer stem cells 1. The discovery of breast cancer stem cells: With the in-depth study of the tumor, the researchers found that tumor cells and normal tissue stems from tissue-like, tumor group