论文部分内容阅读
目的分析C-反应蛋白(CRP)、血清前白蛋白(PA)、血清降钙素原(PCT)对儿童医院感染诊断中的应用以及评价关系,为临床检查及治疗提供帮助。方法对2012年4月-2013年10月医院儿科收治的81例医院感染患儿进行观察,并与同期随机抽取的100名体检正常儿童进行对比分析,比较两组患儿的CRP、PA、PCT,以及感染患儿治疗前后变化情况,采用SPSS 17.0软件进行统计分析。结果感染患儿治疗前CRP与PCT浓度明显高于对照组,而PA浓度明显低于对照组,差异有统计学意义(P<0.05);治疗一周后感染组CRP与PCT浓度大幅降低,PA浓度显著升高,治疗前、后CRP、PA、PCT比较差异有统计学意义(P<0.05);cutoff值CRP为0.81mg/L、PA为9.20mg/L、PCT为0.14μg/L;联合应用检测敏感度提高至97.4%,特异性提高至98.5%。结论CRP、PA、PCT检测对儿童医院感染的临床诊断具有较高的特异性及敏感性,联合动态检测不仅能提高感染性疾病的早期诊断,而且还能反映感染程度及治疗效果,值得临床推广和应用。
Objective To analyze the application and evaluation of C-reactive protein (CRP), pre-serum albumin (PA) and serum procalcitonin (PCT) in the diagnosis of nosocomial infections in children and provide help for clinical examination and treatment. Methods 81 cases of nosocomial infection hospitalized in pediatrics from April 2012 to October 2013 were observed and compared with 100 normal children in the same period. CRP, PA and PCT were compared between the two groups , As well as changes in children with infection before and after treatment, using SPSS 17.0 software for statistical analysis. Results The levels of CRP and PCT before treatment in children with infection were significantly higher than those in control group, but the concentrations of PA were significantly lower than those in control group (P <0.05). The concentrations of CRP and PCT decreased significantly after 1 week of treatment, (P <0.05). The cutoff value of CRP was 0.81mg / L, the PA was 9.20mg / L, the PCT was 0.14μg / L. The combination of Detection sensitivity increased to 97.4%, specificity increased to 98.5%. Conclusion The detection of CRP, PA and PCT has high specificity and sensitivity in the clinical diagnosis of nosocomial infections in children. Combined dynamic examination can not only improve the early diagnosis of infectious diseases, but also reflect the degree of infection and the therapeutic effect, which is worthy of clinical promotion And application.