以可卡因为原料经水解、脱水、甲酯化、4-氯苯基溴化镁格氏反应、酯水解、酰氯化、酰胺化、酰胺还原、烷基化、酰胺还原、脱巯基保护基等反应 ,合成了配体 TRODAT- 1 ( 2 )。用氯化亚锡作还原剂 ,与高锝酸盐溶液反应 ,生成的多巴胺转运蛋白显像剂 99m Tc( V) - TRODAT- 1 ( 1 ) ,放射化学纯度大于 95% ,稳定性好 With cocaine as the raw material by hydrolysis, dehydration, methyl esterification, 4-chlorophenyl magnesium bromide Grignard reaction, ester hydrolysis, acid chloride, amidation, amide reduction, alkylation, amide reduction, de-mercapto- , The ligand TRODAT-1 (2) was synthesized. 99m Tc (V) - TRODAT-1 (1), a dopamine transporter imaging reagent, was synthesized with stannous chloride as reducing agent and reacted with pertechnetate solution. The radiochemical purity was more than 95% and the stability was good