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目的 :研究芬太尼 (F)和氯胺酮 (K)的相互作用.方法 :催眠 :测定小鼠翻正反射消失的发生率和持续期 ;镇痛 :小鼠热板法、电刺激法和扭体法 ;LD50 测定 :小鼠序贯法 ;血压测定 :兔直接插管法 ;呼吸频率测定 :兔游离剑突法.结果 :F加强K的催眠、镇痛效应和呼吸抑制作用 ,拮抗K的升压反应.除非剂量太大 ,F对小鼠静注K之LD50无明显影响.结论 :F可增强K的麻醉作用 ,减轻K的升压反应 ,二者组成复合麻醉是合理的.“,”Objective:Tostudytheinteractionbetweenfentanyl(F)andketamine (K) .Methods:Hypnosia :tomea suretheincidenceanddurationoflossofrightingreflexinmice.Analgesia :hotplate ,electricalstimulationandwrithingtest inmice .MeasurementofLD50 ,bloodpressureandrespiratoryfrequency :sequentialanalysis,directinbationanddissociatingdiaphgraminconciousmiceandrabbits.Resslts:Fenhancedhypnosia ,analgesiaandrespiratoryinhibitionandantagonizedhypertensioninducedbyK .FdidnotaltertheLD50 ofKunlessthedoseofFwasmuchlarger.Conclusion :Fpotentiates anestheticeffectsandattenuateshypertensionofK .ThecombationofFandKinbalancedanesthesiamaybereasonable .