氟哌酸(Norfloxacin)Ia(R=H)和甲基氟哌酸(Pefloxacin)Id(R=Me)。皆为第三代吡酮酸类抗菌药物的优秀代表之一,它们抗菌谱广、抗菌作用强,与其他抗生素之间无交叉耐药性。尤其对包括绿脓杆菌在内的革兰氏阴性细菌的作用,不仅超过同类老品种萘啶酸、吡哌酸等,而且明显强于复方新诺明、四环素、庆大霉素、丁胺卡那霉素等,可与第三代头 Norfloxacin Ia (R = H) and Pefloxacin Id (R = Me). They are all excellent representatives of the third-generation pyrazolonic acid antibiotics, which have wide antibacterial spectrum, strong antibacterial activity and no cross-resistance with other antibiotics. In particular, the role of gram-negative bacteria, including Pseudomonas aeruginosa, not only surpassed that of the same old species nalidixic acid and pipemidic acid, but was significantly stronger than that of cotrimoxazole, tetracycline, gentamycin, amikacin Natamycin, etc., with the third generation of head