论文部分内容阅读
1例68岁男性患者因腹腔镜贲门癌根治术后出现感染,静脉滴注莫西沙星0.4 g,1次/d。第10天患者出现巩膜黄染,实验室检查示总胆红素58.6μmol/L,直接胆红素37.4μmol/L,碱性磷酸酶(ALP)130 U/L,γ-谷氨酰转移酶(γ-GT)147 U/L,丙氨酸氨基转移酶(ALT)25 U/L,天冬氨酸转氨酶(AST)38 U/L。第13天ALT升至1582 U/L、AST升至3285 U/L。立即停用莫西沙星,改用亚胺培南西司他丁钠抗感染,同时给予还原型谷胱甘肽2.7 g静脉滴注,1次/d。停用莫西沙星后27 d,除ALP和γ-GT仍高于正常值外,患者的其他肝功能指标均恢复正常。
A 68-year-old male patient was infected with laparoscopic cardia cancer after radical gastrectomy. Moxifloxacin was infused intravenously 0.4 g once daily. Scleral yellow staining appeared on the 10th day. Laboratory tests showed that total bilirubin 58.6μmol / L, direct bilirubin 37.4μmol / L, alkaline phosphatase (ALP) 130 U / L, γ-glutamyl transferase (γ-GT) 147 U / L, alanine aminotransferase (ALT) 25 U / L, aspartate aminotransferase (AST) 38 U / L. ALT rose to 1582 U / L on day 13 and AST rose to 3285 U / L. Immediate deactivation of moxifloxacin, switch to imipenem cilastatin sodium anti-infection, while given 2.7 g of reduced glutathione intravenous infusion, 1 / d. On day 27 after deactivation of moxifloxacin, all other indicators of liver function returned to normal except ALP and γ-GT were still higher than normal values.