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目的 比较研究E838、WR 2 72 1、盐酸胱胺和炔雌醇等对放射损伤的防治作用及其相互之间的协同作用关系。方法 采用小鼠腹腔注射或灌胃的方法在致伤前或 /和致伤后按常用量给药 ,观察 30d存活率、死亡动物平活日和保护系数K的差异。结果 (1 )致伤前预防给药 ,上述 4种药物均明显提高了放射损伤的存活率 ,并延长了死亡动物的平均存活日 ,其中以E838和WR2 72 1效果最佳 ;(2 )致伤后给药则仅E838和茜草显示了治疗效果 ;(3)联合用药实验显示所研究的 5种配伍用药方式均有较好的防治效果 ,但以WR2 72 1 (防 ) +E838(治 )效果最好。结论 E838和WR2 72 1与其它抗放药相比具有较理想的辐射防护作用 ,且E838还有一定的治疗作用 ,两者合理配伍使用可发挥协同作用效果
Objective To compare the preventive and therapeutic effects of E838, WR 2 72 1, cystamine hydrochloride and ethinyl estradiol on radiation injury and their synergistic effects with each other. Methods The mice were injected intraperitoneally or intragastrically before and / or after injury. The animals were dosed daily with the same dosage. The survival rate at 30 days, the daily life of the deceased animals and the protective factor K were observed. Results (1) Pretreatment prophylaxis, the four drugs significantly increased the survival rate of radiation injury and prolonged the average survival of dead animals, of which E838 and WR2 72 1 best; (2) induced E838 and Rubia cordifolia showed the therapeutic effect only after the injury; (3) The combination therapy experiment showed that the five kinds of drug combinations studied had better prevention and treatment effects. However, WR2 72 1 (anti) + E838 best effect. Conclusion E838 and WR2 72 1 have better radioprotective effect than other anti-lethal drugs, and E838 has certain therapeutic effect. The two drugs can work synergistically