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应用犬蛔虫（Ｔ．ｃａｒｎｉｓ）的感染性虫卵口饲感染Ｃ３Ｈ／ＨｅＮ鼠，体外培养后观察脾细胞的免疫学变化。感染第１－４周的脾细胞用ＣｏｎＡ刺激，Ｔ细胞的增殖反应，ＩＬ－２的诱生均明显地受到抑制，而且感染鼠脾细胞抑制了正常鼠脾细胞对ＣｏｎＡ的反应。感染鼠的脾细胞经ＳｅｐｈａｄｅｘＧ－１０过柱后，Ｔ细胞则不显示被抑制作用。表明影响Ｔ细胞被抑制作用的是感染鼠的巨噬细胞。相反，感染第１－４周的鼠所产生的ＩｇＧ和ＩｇＭ等抗体的Ｂ细胞活性增强；用ＬＰＳ刺激巨噬细胞诱生的白介素（ＩＬ）ＩＬ－１也增多。
The infected C3H / HeN mice were infected with infectious worms of T.carnis, and the immunological changes of splenocytes were observed in vitro. Splenocytes from the first week to the fourth week of infection were stimulated with ConA, the proliferation of T cells and the induction of IL-2 were significantly inhibited, and the infection of splenocytes inhibited the response of ConA to normal splenocytes. Infected mouse spleen cells by SephadexG-10 after the column, T cells did not show inhibition. It is shown that murine macrophages are affected by the suppressive effect on T cells. In contrast, B-cell activity of antibodies such as IgG and IgM produced by mice infected with the first week 1-4 was enhanced; interleukin (IL) IL-1 induced by stimulation of macrophages with LPS also increased.