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目的探讨胰十二指肠切除联合125I粒子治疗胰头癌的效果。方法51例行胰十二指肠切除(pancreaticoduodenectomy,PD)的胰腺癌患者,其中20例行标准胰十二指肠切除术(标准PD组),31例行标准PD术联合腹膜后125I离子植入治疗(联合PD组),比较2组手术情况、组织病理情况及并发症发生率,采用Kaplan-Meier方法分析2组生存率。结果 2组手术时间、术后住院时间、脉管癌栓、神经浸润发生率、分化程度及并发症发生率差异均无统计学意义(P>0.05);标准PD组中位生存期(14个月)与术后1、2、3a生存率(66.7%、30.8%、17.1%)明显低于联合PD组(29个月、82.7%、55.4%、28.1%)(P<0.05)。结论标准胰十二指肠切除联合125I粒子治疗胰头癌可提高患者生存率。
Objective To investigate the effect of pancreaticoduodenectomy combined with 125I particles in the treatment of pancreatic head cancer. Methods Twenty-one patients with pancreatic cancer underwent pancreaticoduodenectomy (PD). Twenty patients underwent standard pancreatoduodenectomy (standard PD) and 31 underwent standard PD combined with retroperitoneal 125I ion implantation (Combined with PD group). The operation, histopathology and complication rates of the two groups were compared. The Kaplan-Meier method was used to analyze the survival rate of the two groups. Results There was no significant difference in operative time, postoperative hospital stay, vascular thrombosis, incidence of nerve infiltration, differentiation degree and incidence of complications (P> 0.05). The median survival time of standard PD group (14 Month) and 1,2,3-year survival rates (66.7%, 30.8%, 17.1%) were significantly lower than those in the combined PD group (29 months, 82.7%, 55.4%, 28.1%). Conclusion Standard pancreatoduodenectomy combined with 125I particles in the treatment of pancreatic cancer can improve the survival rate of patients.