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目的:观察牙周治疗前后种植体周围炎龈沟液高迁移率族蛋白B1(HMGB1)的含量变化和临床意义。方法:随机选取50例种植体周围炎患者和50例种植后无种植体周围炎患者,在牙周洁治前、洁治后、龈下刮治后分别提取种植体周围龈沟液,采用ELISA法对比研究龈沟液中HMGB1浓度水平的变化。结果:种植体周围炎患者龈沟液HMGB1含量较高,刮治后龈沟液HMGB1浓度和健康种植体龈沟液HMGB1浓度相近,差异具有统计学意义(P>0.05)。结论:HMGB1是参与种植体周围炎的重要炎性因子。
Objective: To observe the changes and clinical significance of high mobility group box-1 protein (HMGB1) in peri-implantated periodontal tissue before and after periodontal treatment. Methods: A total of 50 patients with peri-implantitis and 50 patients without peri-implantitis were selected randomly. Peri-implant gingival crevicular fluid was collected before and after radical gingival scaling. ELISA was used to compare To study the changes of HMGB1 concentration in gingival crevicular fluid. Results: The content of HMGB1 in gingival crevicular fluid in peri-implantitis patients was higher than that in gingival crevicular fluid, and the difference was statistically significant (P> 0.05). Conclusion: HMGB1 is an important inflammatory factor involved in peri-implantitis.