5-氨基水杨酸缓释剂在美国和欧洲自80年代初开始发掘与研究,于80年代末、90年代初进入临床,其药代动力学和肠道pH间的关系与其效果有至为重要的关联。本文重点叙述其吸收、分布、蛋白结合、清除、局部与全身性生物利用度,及其与肠道pH和效果的关系。 5-Aminosalicylate sustained-release agent in the United States and Europe since the early 80s began to explore and research, in the late 80s, early 90s into clinical, its pharmacokinetics and the relationship between intestinal pH and its effects are as high as Important connection. This article focuses on its absorption, distribution, protein binding, clearance, topical and systemic bioavailability, and its relationship to intestinal pH and efficacy.