论文部分内容阅读
目的:观察拉米夫定初始联合阿德福韦酯及中药治疗慢性乙型肝炎的临床疗效。方法:将60例慢性乙型肝炎患者随机分为观察组、对照组各30例。2组均给予拉米夫定100 mg/次,1次/d初始治疗,第2个月时加用阿德福韦酯10 mg/次,1次/d,口服。2组均行维生素B、维生素C等常规护肝治疗。观察组同时给予中药水煎分服,1剂/d。2组均以1个月为1个疗程,治疗2个疗程后观察疗效。结果:观察组显效43例,占95.6%;部分有效1例,占2.2%;无效1例,占2.2%;总有效率为97.8%。对照组显效28例,占62.2%;部分有效8例,占17.8%;无效9例,占20.0%;总有效率为80.0%。观察组总有效率明显优于对照组(P<0.05)。ALT、AST、e抗原转阴率、e抗原血清转换率、耐药率、TBIL等指标2组治疗前后均明显好转(P<0.05),观察组改善较对照组明显(P<0.05)。结论:拉米夫定初始联合阿德福韦酯及中药治疗慢性乙型肝炎临床疗效显著。
Objective: To observe the clinical efficacy of lamivudine combined with adefovir dipivoxil and traditional Chinese medicine in the treatment of chronic hepatitis B patients. Methods: Sixty patients with chronic hepatitis B were randomly divided into observation group and control group with 30 cases each. 2 groups were given lamivudine 100 mg / time, 1 / d initial treatment, the second month plus adefovir dipivoxil 10 mg / time, 1 / d, orally. 2 groups were treated with vitamin B, vitamin C and other conventional liver protection. Observation group also given Chinese medicine decoction points, 1 / d. 2 groups were 1 month for a course of treatment, after 2 courses of treatment to observe the effect. Results: The observation group was markedly effective in 43 cases, accounting for 95.6%; partially effective in 1 case, accounting for 2.2%; ineffective in 1 case, accounting for 2.2%; the total effective rate was 97.8%. In the control group, 28 cases were markedly effective, accounting for 62.2%; some were effective in 8 cases, accounting for 17.8%; 9 cases were ineffective, accounting for 20.0%; and the total effective rate was 80.0%. The total effective rate in the observation group was significantly better than that in the control group (P <0.05). ALT, AST, e antigen negative rate, e antigen seroconversion rate, drug resistance rate, TBIL and other indicators of 2 groups were significantly improved before and after treatment (P <0.05), the observation group improved compared with the control group (P <0.05). Conclusion: The initial clinical efficacy of lamivudine combined with adefovir dipivoxil and traditional Chinese medicine in the treatment of chronic hepatitis B is significant.