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患者女,40岁,2年前发现两眼周围皮肤及口唇粘膜颜色变黑并逐渐加深,X线钡剂灌肠提示结肠有多发性息肉。近5年来有慢性腹泻,糊状便,无里急后重。体检:体型胖,两眼上下眼皮和口周皮肤颜色明显发黑,上下唇及口腔内粘膜有大小不等、颜色深浅不一的色素沉着斑,两侧指趾末端掌侧及两侧手掌,足底皮肤见有同样的色素沉着斑,呈对称性。空腹血糖140～176mg/dl,尿糖(+～+++)。钡剂灌肠发现结肠有多发性息肉。肠镜发现直肠、乙状结肠有球状息肉6个,脾曲、肝曲处各一个。息肉病理学检查
The patient, 40 years old, discovered two years ago that the mucous membranes around the eyes and mouth became darker and darker, and X-ray barium enema suggested multiple polyps of the colon. In the past 5 years, there has been chronic diarrhea, mushy stool, no urgency and weight. Physical examination: body fat, two upper and lower eyelids and perioral skin color is obviously dark, upper and lower lip and oral mucosa with varying sizes, color depth of pigmentation spots, both sides of the palms of the fingers on both sides and palms, Plantar skin showed the same pigmentation and symmetry. Fasting blood glucose 140 ~ 176mg/dl, urine sugar (+ ~ +++). Barium enema found multiple polyps in the colon. Colonoscopy found that there were six spherical polyps in the rectum and sigmoid colon, one spleen and one in the liver. Polyp pathological examination