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4例患者(3例男性,1例女性,年龄22～60岁)分别诊断为病毒性脑炎、症状性癫痫、三叉神经痛和脑出血,服用卡马西平0.1～0.2g,3次/d。1个月内均出现神志淡漠、嗜睡、食欲不振等,血钠水平分别从141.0、143.0、141.6和139.8mmol/L降至122.2、112.1、121.8和116.6mmol/L。4例患者遂即停用卡马西平,换用其他药物并接受对症支持治疗。1周后血钠水平分别恢复至138.0、144.0、139.2和144.2mmol/L。
Four patients (3 males and 1 females, aged 22 to 60 years) were diagnosed as viral encephalitis, symptomatic epilepsy, trigeminal neuralgia and intracerebral hemorrhage. Carbamazepine 0.1-0.2g was given for 3 times daily . One month later, there was indifference, drowsiness, loss of appetite, and serum sodium levels decreased from 141.0, 143.0, 141.6 and 139.8 mmol / L to 122.2, 112.1, 121.8 and 116.6 mmol / L, respectively. Four patients then discontinued carbamazepine, switching to other medications and receiving symptomatic supportive care. After 1 week, serum sodium levels were restored to 138.0, 144.0, 139.2 and 144.2 mmol / L respectively.