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目的 对脂溢性角化病 (SK)及侵袭性癌进行DNA定量分析 ,以回顾性探讨两者之间的关系。方法 应用HI CI真彩色病理图像分析仪对 9例SK、16例鳞癌 (SCC)进行DNA倍体图像分析。结果 SCC多呈现C5、>C5 ,SK多呈现C3 4,但 1例SK组织病理示增生活跃 ,DNA倍体分析出现少量 ( 7.8% )的 >C5细胞 ,与SCC比较差异显著 (P <0 .0 1) ,提示部分染色体已发生了质变 ,有癌变潜在可能。结论 如临床上遇到SK有增大趋势 ,需取材做组织病理及DNA含量分析 ,对预测潜在的癌发生有重要价值。
Objective To quantitatively analyze the DNA of seborrheic keratosis (SK) and invasive carcinoma in order to explore the relationship between the two. Methods Ninety-one cases of SK and 16 cases of squamous cell carcinoma (SCC) were analyzed for DNA ploidy using HI CI True Color Pathology Image Analyzer. Results Most of the patients with SCC showed C5, C5 and SK. However, one patient showed hyperplasia of histopathology and a small amount of> C5 cells in DNA ploidy analysis, which was significantly different from that of SCC (P <0.05). 0 1), suggesting some chromosomal changes have taken place, there is the potential cancer. Conclusions If clinically encountered SK increasing trend, the need to take samples for histopathology and DNA content analysis, the prediction of potential cancer has important value.