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肝纤维化是肝损伤后的修复反应,涉及一系列复杂的分子及细胞机制,如何制备与人类肝纤维化相似的动物模型,不仅是深入研究肝纤维化及肝硬化发病机制的重要基础,也是筛选防治药物的有效手段。本文重点讨论制备大鼠、小鼠和家兔肝纤维化及肝硬化动物模型的不同研究方法。
Liver fibrosis is a repair reaction after liver injury involving a series of complex molecular and cellular mechanisms. How to prepare an animal model similar to human liver fibrosis is not only an important basis for further research on the pathogenesis of liver fibrosis and cirrhosis, but also Screening effective means of prevention and treatment of drugs. This article focuses on the preparation of rat, mouse and rabbit liver fibrosis and animal models of liver cirrhosis different research methods.