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目的探讨卡铂在鼻咽癌放射治疗中的增敏作用。方法 89例鼻咽癌患者随机分为两组。单纯放疗组 (对照组 )4 3例 ,卡铂联合放疗组 (治疗组 ) 4 6例 ,两组放疗方式及剂量相同。治疗组在放疗第 1、3、5周放疗前应用卡铂 ,每次10 0mg ,静滴 ,每周 5次。 结果鼻咽肿瘤及颈淋巴结转移灶完全消退率治疗组明显高于对照组 (P <0 .0 5 )。 3年内局部复发及远处转移治疗组明显低于对照组 ,分别是 10 .9%、15 .2 %和 2 7.9%、34.9%,均有显著性差异。 3年生存率治疗组、对照组分别是 78.3%、5 8.1%(P <0 .0 5 )。结论放疗联合适量卡铂化疗 ,起到一定的放射增敏作用 ,并能抑制或延缓肿瘤复发及远处转移 ,可提高鼻咽癌患者的生存期。
Objective To investigate the sensitizing effect of carboplatin in radiotherapy of nasopharyngeal carcinoma. Methods 89 patients with nasopharyngeal carcinoma were randomly divided into two groups. In the radiotherapy alone group (control group), 43 patients received carboplatin combined with radiotherapy (treatment group), 46 patients received the same radiotherapy method and dose. The treatment group in the first, third and fifth week of radiotherapy radiotherapy carboplatin, each 10mg, intravenous infusion, 5 times a week. Results The complete regression rate of nasopharyngeal tumor and cervical lymph node metastasis in the treatment group was significantly higher than that in the control group (P <0.05). The local recurrence and distant metastasis in the three years were significantly lower than those in the control group (10.9%, 15.2% and 29.9%, 34.9%, respectively). The 3-year survival rates in the treatment group and the control group were 78.3% and 51.8%, respectively (P <0.05). Conclusion Radiotherapy combined with appropriate carboplatin chemotherapy, radiosensitization play a role, and can inhibit or delay tumor recurrence and distant metastasis, can improve the survival of patients with nasopharyngeal carcinoma.