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Aims: To explore the therapeutic effect of electroacupuncture (EA) for treatment of male immune-infertility patients and to observe the effect of EA on antisperm antibody (AsAb) positive reaction. Methods: A total of 100 male infertility AsAb-positive patients were randomized into EA group (n = 50, BL- 15, BL- 17, -18, -23, etc. ) and medication group (n=50, oral administration of prednisone, 5 mg/time, t. i. d. ). Serum and sperm AsAb were determined with enzyme immunoassay technique. Results: Following 4 months treatment, the cure rates and the total effective rates of EA and medication groups were 40.4% (20 cases/50 cases) and 92.0% (45/50), 10.0% (5/50) and 64.0% (32/50) respectively. The cure rate of EA group was significantly superior to that of medication group (P＜0.01). But, no significant difference was found between two groups in the total effective rate (P ＞0.05). After treatment, AsAb positive rates of both groups particularly that of EA group decreased significantly compared with pre-treatment of each group (P＜0.05-0.01). Conclusion: EA treatment can work well in the treatment of some immune-mediated male infertility patients and possesses a favorable regulation action on AsAb reaction.