探讨硝酸异山梨酯注射液导致老年男性急性尿潴留的致病机理。通过临床观察24例老年男性患者使用硝酸异山梨酯注射液后导致急性尿潴留,结合硝酸异山梨酯注射液的药理作用,分析其机理主要如下:1膀胱为一肌性器官,硝酸异山梨酯对膀胱平滑肌也有舒张作用,可使膀胱逼尿肌松弛;2对于老年男性,硝酸异山梨酯注射液扩血管后可使前列腺充血加重,使尿路梗阻加重,出现尿潴留;3由于前列腺包膜和腺体均有肾上腺素α受体,硝酸异山梨酯恰恰拮抗肾上腺素血管紧张素的α受体而使梗阻加重,出现尿潴留,尤其前列腺肥大患者静脉滴注硝酸异山梨酯注射液更易导致尿潴留。在临床应用硝酸异山梨酯注射液治疗过程中应多加注意,避免给患者带来不必要的痛苦和经济负担。 To investigate the pathogenic mechanism of isosorbide dinitrate injection in acute urinary retention in elderly men. Clinical observation of 24 elderly male patients with isosorbide dinitrate injection caused acute urinary retention, combined with the pharmacological effects of isosorbide dinitrate injection, the analysis of the mechanism are as follows: 1 bladder as a muscular organ, isosorbide dinitrate Bladder smooth muscle also has a relaxation effect, can detrusor decumbent muscle relaxation; 2 for elderly men, isosorbide dinitrate injection vasodilator can make the prostate hyperemia, so that increased urinary tract obstruction, urinary retention; 3 due to the prostate capsule and Gland are adrenaline α receptor, isosorbide dinitrate just antagonize the adrenergic angiotensin receptor α and obstruction, increased urinary retention, especially in patients with prostatic hypertrophy intravenous infusion of isosorbide dinitrate more likely to lead to urine Retention. In the clinical application of isosorbide dinitrate injection treatment should pay more attention to avoid unnecessary suffering and financial burden on patients.