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目的对高低通量血液透析膜清除溶质的能力进行比较。方法将医院于2010年7月至2013年4月收治的98例维持性血液透析患者随机分成两组,试验组使用F60聚砜膜血液透析器,对照组使用F6聚砜膜血液透析器;对两组患者进行每周3次的血液透析,并对透析前后患者的血尿素氮、肌酐、血磷浓度及血β2-微球蛋白的含量进行检测并比较。结果两组患者透析后的血尿素氮、肌酐及血磷浓度均有明显下降但两组下降值差异不显著;试验组患者透析后血β2-微球蛋白的含量较对照组有明显下降(P<0.05),数据具有统计学方面的意义。结论高低通量血液透析膜对尿素氮、肌酐及血磷等小分子溶质的清除效果大致相同,但高通量血液透析膜对血β2-微球蛋白等大分子溶质的清除能力明显优于低通量血液透析膜。
Objective To compare the ability of high and low flux hemodialysis membranes to remove solutes. Methods A total of 98 patients with maintenance hemodialysis admitted from July 2010 to April 2013 in our hospital were randomly divided into two groups. F60 polysulfone membrane hemodialyzer was used in the experimental group and F6 polysulfone membrane hemodialyzer was used in the control group. Two groups of patients were hemodialysis three times a week. The levels of blood urea nitrogen, creatinine, serum phosphorus and blood β2-microglobulin before and after dialysis were detected and compared. Results The levels of blood urea nitrogen, creatinine and phosphorus after dialysis were significantly decreased in both groups, but there was no significant difference between the two groups. The content of β2-microglobulin in the experimental group was significantly lower than that in the control group (P <0.05), the data has a statistical significance. Conclusions High and low flux hemodialysis membrane has the same removal effect on small molecule solutes such as urea nitrogen, creatinine and phosphorus, but the clearance ability of high-throughput hemodialysis membrane on solutes such as blood β2-microglobulin is obviously better than that of high-throughput hemodialysis membrane Flux hemodialysis membrane.