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目的：为了探讨ＩＦＮγ在增强宿主防御沙门氏伤寒菌感染中的作用机制。方法：采用体外细胞培养方法研究了ＩＦＮγ对ＴＨＰ１细胞应答沙门氏伤寒菌的调节作用。结果：发现ＩＦＮγ显著促进ＴＨＰ１细胞及ＰＭＡ分化的ＴＨＰ１细胞内化和杀伤沙门氏伤寒菌，并明显增强沙门氏伤寒菌诱导ＰＭＡ分化的ＴＨＰ１细胞产生ＴＮＦα和增强诱导ＴＨＰ１细胞及ＰＭＡ分化的ＴＨＰ１细胞产生ＩＬ１２。结论：ＩＦＮγ在调节宿主单核吞噬细胞应答沙门氏伤寒菌感染中起着重要作用
Objective: To investigate the mechanism of IFN γ in enhancing host defense against Salmonella typhi. Methods: The in vitro cell culture method was used to study the regulation of IFN-γ on THP 1 cells in response to Salmonella typhi. Results: Found that IFN γ significantly promote THP 1 cells and PMA differentiation of THP 1 cells internalization and killing of Salmonella typhi, and significantly enhanced Salmonella typhimurium induced PMA differentiation THP 1 cells produce TNF @ and enhanced Induced THP 1 cells and PMA differentiated THP 1 cells produce IL 12. Conclusion: IFNγ plays an important role in the regulation of host mononuclear phagocytes in response to Salmonella typhi.