骨的原发性非霍奇金恶性淋巴瘤是一种少见的原发于骨组织的恶性肿瘤,其病变可累及全身骨骼,侵犯部位以股骨及骨盆为最多[1]。肿瘤多为单发,亦可呈多发性改变[2]。本文报告1例经病理证实,同时发生在股骨和胫骨的病例。1　病历报告　　　患者,女,38岁。主诉左侧下肢无力,同侧膝部 Primary non-Hodgkin’s lymphoma of the bone is a rare malignant tumor of bone origin, and its lesions can affect the whole body. The majority of the invaded sites are the femur and pelvis [1]. Most of the tumors are single-shot, but they can also show multiple changes [2]. This article reports a case confirmed by pathology and occurred simultaneously in the femur and tibia. 1 Medical record report The patient, female, is 38 years old. Complaints left lower limb weakness, ipsilateral knee