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目的:探讨艾灸及艾烟对化疗所致白细胞减少症模型小鼠的影响。方法:50只清洁级ICR雄性小鼠随机分为空白组、模型组、艾烟组、无烟灸组、艾灸组,各组连续干预5d后,除空白组外其余各组小鼠腹腔注射环磷酰胺形成白细胞减少症,造模结束后继续干预7d,记录各组小鼠一般情况及体质量变化,采用全自动血细胞分析仪检测血细胞变化,计算各组小鼠脾脏指数及胸腺指数,观察脾脏及胸腺组织病理变化。结果:模型组造血功能相对于空白组显著抑制(P<0.01,P<0.05)。干预后,艾灸组及艾烟组的白细胞计数(WBC)显著高于模型组(P<0.05),脾脏指数显著低于模型组(P<0.01),胸腺指数显著高于模型组(P<0.01)和无烟灸组(P<0.05)。组织病理学观察,模型组脾、胸腺有不同程度的变性、坏死,艾灸组及艾烟组免疫器官损伤程度较模型组及无烟灸组低。结论:艾灸及艾烟可通过改善造血功能及保护免疫器官,对白细胞减少症能起到一定的治疗作用。
Objective: To investigate the effects of moxibustion and Aiyan on chemotherapy-induced leukopenia mice. Methods: Fifty clean ICR male mice were randomly divided into blank group, model group, Ai-fu group, smoke-free moxibustion group and moxibustion group. After continuous intervention for 5 days in each group, mice in other groups except the blank group were intraperitoneally injected Cyclophosphamide to form leukopenia, continue intervention after the completion of modeling 7d, the general conditions and body weight changes were recorded in each group of mice, automatic blood cell analyzer was used to detect changes in blood cells, calculate the mouse spleen index and thymus index, observed Pathological changes of spleen and thymus. Results: The hematopoietic function of the model group was significantly inhibited compared with the blank group (P <0.01, P <0.05). After intervention, the WBC in moxibustion group and AI group were significantly higher than that in model group (P <0.05), the spleen index was significantly lower than that in model group (P <0.01), and thymus index was significantly higher than that in model group (P < 0.01) and smokeless moxibustion group (P <0.05). Histopathological observation showed that the spleen and thymus of the model group had varying degrees of degeneration and necrosis. The degree of immune organ damage in the moxibustion group and the Ai smoke group was lower than that in the model group and the smokeless moxibustion group. Conclusion: Moxibustion and Aiyan can play a certain therapeutic effect on leukopenia by improving hematopoietic function and protecting immune organs.