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目的:探讨2型糖尿病患者维生素D缺乏与下肢动脉疾病的相关性。方法:选取2型糖尿病患者206例,根据血25(OH)D3浓度分为维生素D缺乏组(<10ng/ml)和维生素D非缺乏组(≥10ng/ml)。采集临床资料数据,测定下肢动脉疾病指标踝肱比(ABI)。对血25(OH)D3水平及ABI的关系进行方差分析及二项分类logistic回归分析。结果:在全部(206例)2型糖尿病患者中,维生素D缺乏组为84例(40.8%),维生素D非缺乏组122例(59.2%)。在维生素D缺乏组与非缺乏组中,已知的下肢动脉疾病危险因素(如年龄、BMI、腰围、高血压、吸烟、总胆固醇)无显著差异。维生素D缺乏组ABI≤0.9的24例(28.6%),维生素D非缺乏组ABI≤0.9的32例(26.2%),两组间比较无显著差异(P>0.05)。二项分类logistic回归分析显示血25(OH)D3浓度与ABI变化无明显相关性。结论:在2型糖尿病患者中,未发现维生素D缺乏与下肢动脉疾病有显著相关性。
Objective: To investigate the relationship between vitamin D deficiency and arterial disease in lower extremities in type 2 diabetic patients. Methods: A total of 206 type 2 diabetic patients were selected and divided into vitamin D deficiency group (<10ng / ml) and vitamin D non - deficiency group (≥10ng / ml) according to the concentration of 25 (OH) D3. Clinical data were collected to determine the ankle-brachial index (ABI) of arterial disease in lower extremities. ANOVA and two classification logistic regression analysis were used to analyze the relationship between serum 25 (OH) D3 level and ABI. RESULTS: Of the total (206) type 2 diabetic patients, 84 (40.8%) had vitamin D deficiency and 122 (59.2%) had vitamin D non-deficiency. There were no significant differences in risk factors for lower extremity arterial disease known as age, BMI, waist circumference, hypertension, smoking, and total cholesterol in the vitamin D-deficient and non-deprivation groups. There were 24 cases (28.6%) with ABI≤0.9 in vitamin D deficiency group and 32 cases (26.2%) with ABI≤0.9 in vitamin D non-deficiency group. There was no significant difference between the two groups (P> 0.05). Binary logistic regression analysis showed no significant correlation between blood 25 (OH) D3 and ABI. CONCLUSIONS: In type 2 diabetic patients, no evidence of a significant association between vitamin D deficiency and lower extremity arterial disease was found.