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甲氧氟烷1958年由 Larsen 合成并发现了它的麻醉性能。1960年 Artusio 对它的麻醉作用进行了首次评述,当时认为它对肾脏无特殊的损害作用。随着该药的广泛使用对其药理作用也逐渐深入了解。1964年Paddock 注意到3例甲氧氟烷麻醉后出现肾功能衰竭并且对其中两例死亡者做了尸检,发现肾小管内有大量草酸钙结晶。1965年North 等发现甲氧氟烷麻醉后血尿素氮升高。到1966年人们便认识到甲氧氟烷会引起多尿性肾功能损害。其中 Crandell 等详细地报告了他们的研究情况,引起了麻醉
Methoxyfopidine was synthesized by Larsen in 1958 and found its anesthetic properties. Artusio first commented on its anesthetic effect in 1960 when it was thought to have no specific detrimental effect on the kidneys. With the widespread use of the drug on its pharmacological effects are gradually in-depth understanding. In 1964, Paddock noticed three cases of renal failure after anesthesia with metofloxacin and autopsy of two of the deaths. He found large amounts of calcium oxalate crystals in the renal tubules. In 1965 North et al found that blood urea nitrogen increased after anesthesia. By 1966, it was recognized that methoxyfoxane causes polyuric renal impairment. Crandell et al. Reported their research in detail and caused anesthesia