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1,2,3-三唑是一类具有重要生物活性的杂环化合物,在医药、农药等领域都得到了广泛的应用。点击化学(click chemistry)的代表反应为铜催化的叠氮-炔基Husigen环加成反应。综述了近年来国内外学者使用不同新型催化剂和试剂进行点击化学(click chemistry),用于合成1,4-二取代、1,5-二取代和1,4,5-三取代1,2,3-三唑衍生物的研究进展。
1,2,3-triazole is a class of important biological activity of heterocyclic compounds, in medicine, pesticides and other fields have been widely used. The representative reaction of click chemistry is the copper-catalyzed azido-alkynyl Husigen cycloaddition reaction. In recent years, the domestic and foreign scholars reviewed the use of different novel catalysts and reagents for click chemistry for the synthesis of 1,4-disubstituted, 1,5-disubstituted and 1,4,5-trisubstituted 1,2, Research Progress of 3-Triazole Derivatives.