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用氯胺Ｔ法标记抗人肝癌单克隆抗体（ＭＣＡｂＪＨⅢ），对荷人肝细胞癌ＢＥＬ－７４０２裸鼠进行体内生物学分布和肿瘤放射免疫显像研究。腹腔注射１３１Ⅰ－ＭＣＡｂＪＨⅢ后２４～１２０ｈ，肿瘤部位的放射性浓聚，以７２～９６ｈ的影像最为清晰；而注射１３１Ⅰ－ｍＩｇＧ则呈全身性均匀分布，无肿瘤部位选择性浓聚现象。１３１Ⅰ－ＭｃＡｂＪＨⅢ注射后７２ｈ，１３种器官的肿瘤组织与非瘤组织的放射性比值均大于５，肿瘤的定位指数为７．０７。这表明ＭＣＡｂＪＨⅢ在肝细胞癌的诊断和导向治疗方面可能有较好的应用价值。
The human anti-human hepatoma monoclonal antibody (MCAbJHIII) was labeled with the chloramine T method and biological distribution and tumor radioimmunoimaging of the human hepatocellular carcinoma BEL-7402 nude mice were studied. After intraperitoneal injection of 131I-MCAbJHIII, the radioactivity concentration of the tumor site was the most clear from 72 to 96 hours after the injection of 131I-MCAbJHIII, while the 131I-mIgG injection was uniformly distributed throughout the body, and there was no selective concentration of tumor sites. At 72 hours after injection of 131I-McAbJHIII, the radioactivity ratios of tumor tissues to nontumor tissues in all 13 organs were greater than 5, and the tumor localization index was 7.07. This indicates that MCAbJHIII may have a good application value in the diagnosis and targeted treatment of hepatocellular carcinoma.