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目的 :探讨胃癌组织中 P5 3蛋白表达和 PCNA评分之间的相关性。方法 :运用免疫组织化学 L SAB方法 ,对 68例原发性胃癌组织进行标记。结果 :P5 3蛋白表达阳性率 4 5 .5 8% (3 1/ 68) ,PCNA评分值 2 .4 0 0±1.0 10 (x± s)。P5 3阳性率和 PCNA评分数在组织学分级 级 ,无淋巴结转移者中明显低于组织学分级 级 ,有淋巴结转移者 ,概率分别为 P<0 .0 5、P<0 .0 1。结论 :P5 3蛋白和 PCNA与胃癌的发生、发展密切相关 ,可能是反映胃癌生物学行为和预测预后的重要标记物
Objective: To investigate the correlation between P53 protein expression and PCNA score in gastric cancer. Methods: 68 cases of primary gastric cancer tissues were labeled by immunohistochemical L SAB method. Results : The positive rate of P53 protein expression was 45.5% (3 1/68), and the PCNA score value was 2.400 ± 1.010 (x±s). The P5 3 positive rate and PCNA score were significantly lower in histological grades without lymph node metastasis than those with histologic grade and lymph node metastases. The probability was P 0. 05 and P 0. 01 respectively. Conclusion: P53 protein and PCNA are closely related to the occurrence and development of gastric cancer, and may be important markers reflecting the biological behavior of gastric cancer and predicting prognosis.