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目的 研究雷公藤多甙 (TripterigiumWilfordiiGlycosides ,TWG)对蛋白尿患者肾血流动力学的作用 ,并与消炎痛比较 ;方法 TWG组和消炎痛组各 1 5例病人 ,治疗前后分别检测尿蛋白定量、肾小球滤过率 (GFR)、肾有效血浆流量 (ERPF)和肾血管阻力 (RVR) ;结果 两组患者尿蛋白排泄均显著减少 ,TWG组治疗后RVR、GFR、ERPF无显著性变化 ,而消炎痛组RVR升高、ERPF下降、GFR无显著性下降 ;结论 消炎痛减少尿蛋白排泄伴ERPF降低和RVR升高 ,而TWG减少尿蛋白排泄而不伴ERPF和RVR变化。
Objective To study the effects of Tripterygium Wilfordii Glycosides (TWG) on renal hemodynamics in patients with albuminuria and compare with indomethacin. Methods Fifteen patients in TWG group and indomethacin group were treated with TWG, Glomerular filtration rate (GFR), renal effective plasma flow (ERPF) and renal vascular resistance (RVR). Results Urinary protein excretion was significantly decreased in both groups. There was no significant change in RVR, GFR and ERPF after TWG treatment, However, indomethacin increased RVR and ERPF but no significant decrease of GFR. Conclusion Indomethacin reduced urinary protein excretion accompanied with ERPF decrease and RVR increase, while TWG decreased urinary protein excretion without change of ERPF and RVR.