目的了解梧州市出生缺陷发生情况及分布特征,为出生缺陷的预防和干预提供依据和对策。方法收集梧州市2001~2006年出生缺陷资料,对资料进行分析。结果6年间共发现出生缺陷儿1529例,平均出生缺陷率为17.41‰,2006年前10位出生缺陷为:胎儿水肿综合征(3.17‰),唇裂合并腭裂(1.61‰),马蹄内翻足(1.51‰),多指(1.46‰),肢体短缩(1.31‰),并指(1.21‰),先天性脑积水(1.01‰),唇裂(0.91‰),无脑畸形(0.55‰),尿道下裂(0.40‰)。结论梧州市2001~2006年出生缺陷发生率呈逐年下降趋势,因此应继续加强卫生知识宣教和婚前医学检查、产前筛查及产前诊断,以预防和减少出生缺陷的发生。 Objective To understand the occurrence and distribution of birth defects in Wuzhou and to provide the basis and countermeasures for the prevention and intervention of birth defects. Methods The data of birth defects in Wuzhou from 2001 to 2006 were collected and the data were analyzed. Results A total of 1529 children with birth defects were found in 6 years. The average birth defect rate was 17.41%. The first 10 birth defects in 2006 were fetal edema syndrome (3.17 ‰), cleft palate (1.61 ‰), clubfoot (1.21 ‰), congenital hydrocephalus (1.01 ‰), cleft lip (0.91 ‰), anencephaly (0.55 ‰) Hypospadias (0.40 ‰). Conclusion The incidence of birth defects in Wuzhou from 2001 to 2006 shows a declining trend year by year. Therefore, health education and premarital medical examination, prenatal screening and prenatal diagnosis should be strengthened to prevent and reduce birth defects.