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本文用银染——G带复合法对胃癌前病变、胃癌患者与正常人的银染核仁形成区(Ag-NOR)作对比研究,结果表明胃粘膜中～重度肠上皮化生或不典型增生的患者,亦如胃癌,有第14号染色体Ag—NOR频率明显减少;在低分化、溃疡型、直径小于5cm的胃癌患者,第15号染色体的Ag—NOR频率减少。提示淋巴细胞Ag—NOR检查可望成为检测肿瘤高风险人群、探索疾病早期诊断、观察肿瘤对机体影响的一种手段。
In this study, a silver staining-G-band complex method was used to compare the silver-staining nucleolar formation region (Ag-NOR) in gastric precancerous lesions, gastric cancer patients and normal individuals. The results showed that the intestinal mucosa was metastatic or atypical in the gastric mucosa. In patients with hyperplasia, such as gastric cancer, there was a significant decrease in the frequency of Ag-NOR on chromosome 14; in gastric cancer patients with poorly differentiated, ulcerated, and less than 5 cm in diameter, the frequency of Ag-NOR on chromosome 15 decreased. It is suggested that the lymphocyte Ag-NOR test is expected to be a means to detect high risk populations of tumors, explore the early diagnosis of the disease, and observe the effects of the tumor on the body.