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目的 探讨血清同型半胱氨酸与2型糖尿病早期肾损害的关系。方法根据糖尿病患者尿微量白蛋白排泄量分组同时检测血清同型半胱氨酸浓度。结果糖尿病患者血清同型半胱氨酸浓度较正常对照组明显升高,随着蛋白尿的增多而血清同型半胱氨酸也相应增加。结论同型半胱氨酸随糖尿病肾病的发生以及严重程度逐渐增高,可作为早期诊断糖尿病肾病较敏感的指标,对于监测早期糖尿病肾病的发生和病情发展程度有重要意义.
Objective To investigate the relationship between serum homocysteine and type 2 diabetes early renal damage. Methods According to the urinary albumin excretion of patients with diabetes mellitus, serum homocysteine concentrations were measured simultaneously. Results Serum homocysteine levels in diabetic patients were significantly higher than those in normal controls, and serum homocysteine increased with the increase of proteinuria. Conclusions Homocysteine gradually increases with the occurrence and severity of diabetic nephropathy, which may be used as a sensitive indicator of early diagnosis of diabetic nephropathy. It is of great significance to monitor the occurrence and progression of early diabetic nephropathy.