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目的:观察盐酸丙卡特罗对小儿持续性咳嗽的临床疗效及安全性。方法:58例患儿随机分为治疗组32例。服盐酸丙卡特罗口服液;对照组26例,服复方氯化铵糖浆,总疗程3周。取治疗前、治疗第6,13,20 d四个观察点,对日、夜间症状评分,并进行两两比较。结果:试验组自身比较,日间、夜间症状评分均有统计学差异。对照组各观察点比较,日间、夜间症状评分,治疗前与治疗第13,20 d相比较,P<0．05。试验组和对照组治疗13,20 d的日间、夜间症状评分有统计学差异。两组患儿在整个疗程中峰流速(PEF)的变异率均小于10％,两组在治疗前、治疗第6,13,20天分别进行组内、组间两两比较,P>0．05;提示在整个疗程中PEF变异率的检测无意义。在整个服药观察期,两组患儿均无不良反应。结论:盐酸丙卡特罗治疗儿童持续性咳嗽,可显著改善患儿的咳嗽症状,具有良好的安全性,依从性好。
Objective: To observe the clinical efficacy and safety of procaterol hydrochloride in children with persistent cough. Methods: Fifty-eight children were randomly divided into treatment group (32 cases). Procaterol hydrochloride oral solution; control group of 26 cases, taking compound ammonium chloride syrup, the total course of treatment for 3 weeks. Take before treatment, treatment of the first 6,13,20 d four observation points, the Japanese and nocturnal symptoms score, and a pair of comparisons. Results: Compared with the experimental group, the symptom scores of daytime and nighttime were statistically different. The control group compared the observation points, daytime and nighttime symptom score, before treatment and treatment on the 13th and 20th day, P <0.05. The test group and control group had statistically significant differences in daytime and nighttime symptom scores on the 13th and 20th day after treatment. The variability of peak flow velocity (PEF) was less than 10% in both groups during the whole course of treatment. Before treatment and on the 6th, 13th and 20th days of treatment, the two groups were compared with each other, P> 0. 05; suggesting that the detection of PEF variability was insignificant throughout the course of treatment. During the entire observation period, both groups had no adverse reactions. Conclusion: Procaterol Hydrochloride in children with persistent cough can significantly improve children’s cough symptoms, with good safety, good compliance.