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目的 了解本地区妊娠肝内胆汁淤积症(intrahepatic cholestasis of pregnancy, ICP)的发病率及发病特点。 方法 从妊娠20~24周开始普查,动态观察至36周以上,以总胆汁酸酶循环法测定血清总胆汁酸(total bile acid,TBA),TBA>28.5μmol /L为异常,同时复查肝功能加以确诊。 结果 共普查1275例,确诊为ICP 的患者102 例,发病率为8.00%。妊娠33~36 周ICP的发病率(66/351,18.80%)明显高于其他不同孕龄组(P<0.01)。少数民族孕妇ICP的发病率(47/328,14.33%)高于汉族孕妇(55/947, 5. 81%) (P< 0. 01)。有ICP 高危因素的患者ICP 发病(10/67,14.93%)高于无高危因素组(92/208,7.62%)(P<0.01)。 结论 克拉玛依地区ICP的发病率为8 00%,为ICP的高发地区。少数民族孕妇ICP的发病率明显高于汉族发病率。ICP的发病与孕周、孕妇年龄、家族、服药史等有一定的相关性。TAB在整个孕期的波动范围较大。
Objective To understand the incidence and incidence of intrahepatic cholestasis of pregnancy (ICP) in this area. Methods Census was started from 20 to 24 weeks of gestation. The total bile acid (TBA) and TBA> 28.5 μmol / L were determined by the method of total bile acid cycle. The liver function Be diagnosed. Results A total of 1275 cases were surveyed, 102 cases were diagnosed as ICP, the incidence was 8.00%. The incidence of ICP (66/351, 18.80%) between the 33th and 36th weeks of pregnancy was significantly higher than that of other gestational age groups (P <0.01). The incidence of ICP in ethnic minority pregnant women (47 / 328,14.33%) was higher than that of Han pregnant women (55/947, 5.81%) (P <0.01). ICP patients with high risk of ICP had higher incidence of ICP (10/67, 14.93%) than those without risk (92/208, 7.62%) (P <0.01). Conclusion The incidence of ICP in Karamay region is 800%, which is a high incidence area of ICP. The incidence of ICP in ethnic minority pregnant women is significantly higher than that of Han nationality. The incidence of ICP and gestational age, pregnant women age, family history of medication have some relevance. TAB throughout the pregnancy a large range of fluctuations.