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目的探讨冠心病合并糖尿病患者糖化血红蛋白与血浆脑钠肽(BNP)相关性。方法选取2013年2月至2014年10月在郑州大学第四附属医院心血管内科住院的冠心病心力衰竭患者100例,其中冠心病合并糖尿病50例,单纯冠心病50例,检测两组患者糖化血红蛋白(Hb A1c)及BNP水平,探讨两者的相关性。结果冠心病合并糖尿病组血浆BNP水平明显高于对照组,差异有统计学意义(P<0.05),且BNP与糖化血红蛋白具有相关性(r=0.48,P<0.05)。结论 Hb A1c水平与糖尿病心力衰竭的发生关系密切,检测Hb A1c水平对防治糖尿病并心力衰竭患者有重要指导价值。
Objective To investigate the relationship between glycohemoglobin and plasma brain natriuretic peptide (BNP) in patients with coronary heart disease complicated with diabetes mellitus. Methods From February 2013 to October 2014, 100 patients with coronary heart disease and heart failure were enrolled in Department of Cardiology, the Fourth Affiliated Hospital of Zhengzhou University. Fifty patients with coronary heart disease complicated with diabetes mellitus and 50 patients with simple coronary heart disease were enrolled in this study. Hemoglobin (Hb A1c) and BNP levels, to explore the correlation between the two. Results Plasma BNP levels in CHD patients with diabetes mellitus were significantly higher than those in controls (P <0.05). BNP was associated with HbA1c (r = 0.48, P <0.05). Conclusion The level of Hb A1c is closely related to the occurrence of heart failure in diabetes. It is of great value to detect the level of Hb A1c in the prevention and treatment of patients with diabetes mellitus and heart failure.