论文部分内容阅读
抗癌药物抑癌效果显著者,往往毒副作用也大,特别对血液,胃肠系统的作用较剧烈,因此用常规的静脉注射或口服法使肿瘤组织有足够的药物浓度而不产生毒副作用的可能性很小。为改善抗癌药物的生物学利用率、减小毒副作用并达到在体内定向分布,以提高疗效,近年来发展了可控释放药物剂型,~1它主要是利用高分子材料作为药物载体,直接埋入病灶部位以增大局部药物浓度,通过缓慢释放药物持续对病灶发生作用达到高效低毒的效果~2。聚乳酸(以下简称PLA)可在人体内逐渐分解为无毒的小分
The anti-cancer drugs with significant anti-cancer effects are often toxic and side effects, especially for the blood and gastrointestinal system. Therefore, conventional intravenous or oral methods are used to make tumor tissues have enough drug concentration without toxic side effects. The possibility is small. In order to improve the bioavailability of anticancer drugs, reduce toxic side effects and achieve targeted distribution in the body to improve efficacy, in recent years the development of controlled release drug formulations, it is mainly the use of polymer materials as drug carriers, direct Embedded in the lesion site to increase the local drug concentration, through the slow release of drugs continue to effect the lesion to achieve the effect of high efficiency and low toxicity ~ 2. Polylactic acid (hereinafter referred to as PLA) can be gradually decomposed into non-toxic fractions in the human body.