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目的探讨联合检测血浆D-二聚体、B型尿钠肽(BNP)和超敏C反应蛋白(hs-CRP)对急性心肌梗死诊断的价值和临床意义。方法选取2015年1-6月在吉林市北华大学附属医院心内科经冠状动脉造影诊断的急性心肌梗死患者46例作为观察组,另外选取同期健康体检者46例作为对照组,采用免疫比浊法检测两组受检者D-二聚体和荧光免疫法检测BNP,Hotgen上转发光免疫分析仪检测hs-CRP水平。结果观察组D-二聚体为(926±253)ng/ml高于对照组的(156±20.3)ng/ml;观察组BNP(681.64±245.47)pg/ml高于对照组的(40.85±26.27)pg/ml;观察组hs-CRP为(20.3±4.96)mg/L高于对照组的(2.7±1.6)mg/L,均差异有统计学意义(P<0.05)。三个指标联合检测的阳性率为93.47%,高于单个指标检测的阳性率。结论急性心肌梗死患者血浆D-二聚体、BNP、hs-CRP水平明显升高,其对于鉴别急性心肌梗死具有非常重要的意义。
Objective To investigate the value and clinical significance of the combined detection of plasma D-dimer, natriuretic peptide (BNP) and hs-CRP in the diagnosis of acute myocardial infarction. Methods 46 cases of acute myocardial infarction diagnosed by coronary angiography at Department of Cardiology, Affiliated Hospital of Beihua University, Jilin Province from January to June 2015 were selected as the observation group. Another 46 healthy subjects were selected as the control group, France test two groups of subjects D-dimer and fluorescent immunosorbent assay BNP, Hotgen light-emitting immunoassay analyzer hs-CRP levels. Results The D-dimer in the observation group was (156 ± 20.3) ng / ml higher than that in the control group (681.64 ± 245.47) pg / ml higher than that in the control group (40.85 ± 26.27) pg / ml. The hs-CRP in the observation group was (20.3 ± 4.96) mg / L higher than that in the control group (2.7 ± 1.6) mg / L, with statistical significance (P <0.05). The positive rate of the combined detection of the three indicators was 93.47%, higher than the positive rate detected by a single indicator. Conclusion The plasma levels of D-dimer, BNP and hs-CRP in patients with acute myocardial infarction are significantly increased, which is of great significance for the differential diagnosis of acute myocardial infarction.