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目的探讨载脂蛋白CIII(apocIII)基因SstI酶切位点多态性与2型糖尿病的关系。方法以apocIII基因为候选基因 ,应用聚合酶链 -限制性片段长度多态性 (PCR -RFLP)方法检测72例2型糖尿病和114例健康人群的apocIII基因多态性。结果广西2型糖尿病人群与非2型糖尿病健康人群的S1 和S2等位基因频率分别为0.792比0.772,0.208比0.228(P>0.05)。结论广西地区2型糖尿病人群与健康人群apocIII基因多态性无显著性差别
Objective To investigate the relationship between apolipoprotein C (apocIII) SstI polymorphism and type 2 diabetes mellitus (T2DM). Methods The apocIII gene polymorphism was detected in 72 cases of type 2 diabetes mellitus and 114 healthy people by polymerase chain-restriction fragment length polymorphism (PCR-RFLP) using apocIII gene as a candidate gene. Results The frequencies of S1 and S2 alleles were 0.792 vs 0.772 and 0.208 respectively than 0.228 (P> 0.05) in Guangxi type 2 diabetes and non-type 2 diabetes. Conclusion There is no significant difference in apocIII gene polymorphism between type 2 diabetes mellitus and healthy population in Guangxi