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前列环素(prostacyclin,PGI_2)是机体多种组织,特别是血管系统中花生四烯酸(AA)代谢的主要产物。近年来,随着对前列腺素(PG)研究的进展,PGI_2的多种生理功能及其临床意义受到了人们的广泛重视。自从发现PGI_2与循环系统的关系以来,PGI_2与呼吸系统、神经系统、消化系统、生殖系统、人类老化及其他多种疾病的关系也逐渐被认识。目前,PGI_2代谢紊乱与疾病的关系及其临床应用,已成为临床的一个重要课题。
Prostacyclin (PGI_2) is a major product of arachidonic acid (AA) metabolism in many tissues of the body, especially in the vascular system. In recent years, with the progress of prostaglandin (PG) research, PGI_2 has many physiological functions and their clinical significance. Since the relationship between PGI_2 and the circulatory system has been discovered, the relationship between PGI_2 and the respiratory system, the nervous system, the digestive system, the reproductive system, human aging and many other diseases has also been gradually recognized. At present, the relationship between PGI2 metabolic disorders and the disease and its clinical application, has become an important clinical issue.